The Spectrum of Renal Osteodystrophy
Features:
* Detailed description of the broad spectrum of renal bone disorders in adults and children
* Discusses implications for growth in children with end-stage renal disease
* Covers diagnosis, treatment and pathogenesis of secondary hyperparathyroidism
* Overviews diagnosis, treatment and pathogenesis of adynamic bone disease
* Reviews soft tissue calcifications and cardiovascular disease
* Details the role of cytokines and growth factors in renal bone disease
* Discusses role of parathyroid hormone related peptide and receptor in skeletal development
Bone deformities, bone and joint diseases and growth retardation have long been of major concern to adults and children with chronic renal failure because of pain and frequently disabling consequences in terms of physical activity. In recent years, our understanding of the underlying causes has made major progress. In addition, new drugs have been developed for the treatment and prevention of the renal bone diseases related to renal failure that will benefit those patients affected with these problems.
Readership:
Adult and pediatric Nephrologists, renal transplant physicians, Endocrinologists and rheumatologists
| Author: |
Tilman Drueke, Isidro Salusky, |
| ISBN: |
0192632302 |
| Publisher: |
Oxford University Press |
| Binding: |
Hardcover |
| Year Published: |
Feb 2002 |
| No. of Pages: |
588 |
| Contents: |
Part I: General aspects of bone turnover and growth 1 New aspects of bone biology
Part II: Normal parathyroid function and PTH action 2 Regulation of PTH secretion and synthesis and of parathyroid cell proliferation 3 Roles of parathyroid hormone-related peptide and the PTH/PTHrP receptor in skeletal development: implications for growth in children with end-stage renal disease
Part III: Pathogenesis of secondary uremic hyperparathyroidism 4 Abnormal PTH synthesis, secretion and metabolism; peripheral tissue resistance to PTH; pathologic parathyroid parathyroid cell growth and apoptosis 5 Parathyroid gland function in patients with renal failure
Part IV; Vitamin D metabolism and action in chronic renal failure 6 Vitamin D metabolism and action in chronic renal failure
Part V: Pathogenetic and clinical aspects of renal bone disease 7 Cytokines and growth factors in renal bone disease 8 Osteitis fibrosa, osteomalacia and mixed bone lesions 9 Adynamic bone disease in uraemia 10 Osteoporosis in uraemia 11 Dialysis-associated amyloidosis 12 Bone diseases in children with chronic renal failure
Part VI: Soft tissue calcification in chronic renal failure 13 Soft tissue calcification in chronic renal failure
Part VII: Non-invasive and invasive diagnosis of renal bone disease 14 Classical serum biochemistry and new biochemical markers 15 X-ray, US, CT and MR imaging of skeleton and joints 16 Imaging and intervention of parathyroid hyperplasia 17 The use of bone histomorphometry in renal osteodystrophy
Part VIII: Prophylaxis and treatment of renal osteodystrophy 18 Medical therapy in predialysis chronic renal failure 19 Medical therapy in dialysis patients 20 Management in renal transplant recipients 21 New vitamin D analogues and calcimimetics 22 Surgical management
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