Familial Breast and Ovarian Cancer
This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. The volume will be of immense value to all clinical geneticists, oncologists, and healthcare professionals involved in screening and counselling programmes.
Key Features:
* Covers molecular biology and natural history, screening, and management
* Includes advice on healthcare provision and setting up cancer genetics services
* Includes the latest developments and their impact on the study and treatment of familial breast and ovarian cancer
| Author: |
Patrick J. Morrison, Shirley V. Hodgson, Neva E. Haites |
| ISBN: |
052180373X |
| Publisher: |
Cambridge University Press |
| Binding: |
Hardcover |
| Year Published: |
Aug 2002 |
| No. of Pages: |
350 |
| Illustrations: |
52 |
| Contents: |
Part I. Molecular Biology and Natural History:
1. Introduction
2. Overview of clinical genetics of breast cancer
3. Cowden syndrome and related disorders
4. Overview of clinical genetics of ovarian cancer
5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes
6. Natural history of hereditary breast cancer
7. Pathology of the breast and ovary in mutation carriers
8. Risk estimation for familial breast and ovarian cancer
Part II. Screening:
9. Experience of setting up a cancer genetics service
10. Referral criteria for cancer genetics clinics
11. Service aspects of cancer genetic clinics
12. Cultural and education aspects influencing development of cancer genetics services in different European countries
13. Screening, detection and survival patterns of breast and other cancers in high risk families
14. Screening for familial ovarian cancer
Part III. Management:
15. Management of BRCA 1/2 mutation carriers
16. Management of ovarian cancer
17. Prophylactic mastectomy in mutation carriers
18. Psychosocial aspects of genetic counselling
19. BRCA 1 and 2 testing: uptake and its measurement
20. Ethical aspects
21. Gene therapy of breast and ovarian cancer
22. Future directions |
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