Non-Myeloablative Allogeneic Transplantation
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.
Non-Myeloablative Allogeneic Transplantation will provide both practitioners and academic clinicians with a better understanding of underlying concepts, current methodologies, and results obtained by the pioneering centres for this rapidly evolving field.
| Author: |
Asad Bashey, Edward D. Ball |
| ISBN: |
0792376463 |
| Publisher: |
Kluwer Academic Publishers |
| Binding: |
Hardcover |
| Year Published: |
March 2002 |
| No. of Pages: |
300 |
| Contents: |
Contributors
Preface.
1. Development of allogeneic hematopoietic stem cell transplantation (HSCT);
2. Immunosuppression with limited toxicity: characteristics of nucleoside analogs and anti-lymphocyte antibodies used in non-myeloablative hematopoietic cell transplantation
3. Mobilization of allogeneic peripheral blood progenitor cells
4. Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies
5. Combined use of autografting and non-myeloablative allografting for the treatment of hematologic malignancies and metastatic breast cancer
6. Non-myeloablative hematopoietic stem cell transplantation (NHT) in the treatment of human malignancies: from animal models to clinical practice
7. Non-myeloablative allogeneic hematopoietic transplantation and induction of graft-versus-malignancy
8. Outpatient allografting in hematologic malignancies and nonmalignant disorders - applying lessons learned in the canine model to humans
9. Non-myeloablative transplants for congenital diseases
Index. |
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| About The Author: |
University of California, San Diego, USA
Edward D. Ball, University of California, San Diego, USA |
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