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Sepsis and Multiple Organ Dysfunction
Sepsis and the multiple organ dysfunction that results from it is one of the commonest causes of death in the ICU.
The last decade has seen an explosion in the understanding of the pathophysiology of sepsis, and progress in critical care medicine has allowed patients to be kept alive long enough for these new technologies to be utilised.
This book aims to be the definitive, gold-standard text on sepsis and multiple-organ dysfunction. It is comprehensive and thoroughly referenced: the one text in which all current knowledge on this important topic is brought together. The book is written by a team of international contributors, overseen by an internationally acclaimed editorial team. It effectively summarises the knowledge from all disciplines.
Features
* Comprehensive, fully referenced source
* Multi-disciplinary contributions from world experts
* Outstanding world expert as main editor
* Academic and totally up-to-date
* Knowledge from all disciplines is summarised
| Author: |
Edwin A Deitch, Jean-Louis Vincent, Alistair Windsor |
| ISBN: |
0702021652 |
| Publisher: |
W. B. Saunders |
| Binding: |
Hardcover |
| Year Published: |
May 2002 |
| No. of Pages: |
516 |
| Illustrations: |
190 |
| Contents: |
1. Introduction and Epidemiology:
* Historical Perspective
* Terminology and Conceptual Challenges
* Multiple Organ Dysfunction: an Introduction
* MODS Following Trauma
* MODS in the Septic/Inflammatory Patient
* MODS in Children
2. Overview of Hypotheses and Putative Factors
* Infection, Sepsis and Septic Shock
* Pathophysiology
* Mediator Response
* Metabolic Response in the Critically Ill
* Ischaemia-Reperfusion Injury
* Coagulation Abnormalities in Sepsis
* Endothelial-Neutrophil Interactions
* The Gut Origin Hypothesis of Multiple Organ Dysfunction
* Effect of Hemorrhage on Immune and Inflammatory Response
* The Two-Hit Model of Multiple Organ Dysfunction
3. Molecular Mechanisms
* Molecular Mechanisms - an Overview
* Apoptosis and Organ Injury
* Heat Shock Proteins
* Biologic Variation and Genetics in the Inflammatory Response
4. Scoring Systems and Diagnosis
* Clinical and Physiologic Scoring Systems for Sepsis and Organ Dysfunction
* Risk Stratification and Outcome
* Inflammatory Serum Markers in Organ Dysfunction
5. Management Principles and Approaches
* Evidence-Based Critical Care Medicine
* Prevention of Organ Injury and MODS
* Principles of Fluid and Inotropic Resuscitation
* Controversies in Resuscitation
* Concepts in Hemodynamic Support
* Is Supranormal Oxygen Delivery Beneficial? Pro and Con
* Gastric Tonometry is ready for Widespread Clinical Use: Pro and Con
* Base Excess and Serum Lactate as Monitors of Resuscitation
* Nutritional Support Current and Future
* Antimicrobial Strategies and Antibiotic Resistance
* Selective Digestive Tract Decontamination Is Effective In Improving Outcomes: Pros And Cons
* Sepsis: Principles of Management
* Empirical Laparotomy In The Patient With Occult Sepsis Is No Longer Necessary: Pro And Con
* Status of the Open Abdomen in Patients with Uncontrolled Abdominal Sepsis
* Immunotherapy (Principles and Current Status)
* Immunotherapy - New Agents
* Septic Shock: What's New
6. Organ Systems and Their Supportive Care
The Lung
* Definitions and Pathophysiology of ARDS
* Nosocomial Pneumonia
* Pulmonary Support
* New Treatments for ARDS
* Liquid Ventilation for Adult Respiratory Failure
The Kidney
* Pathogenesis of Acute Renal Failure: the role of sepsis
* Renal Replacement and Support
Liver and Intestine
* Management of Acute Liver Failure
* Gut Barrier Failure
Heart
* Myocardial Dysfunction in Sepsis
* Hematologic Failure
* Central Nervous System Dysfunction in Sepsis
Intensive Care Issues
* Pharmocokinetics in the Critically Ill
* Sedation, analgesia and muscle relaxation in the intensive care unit
* Abdominal Compartment Syndrome in the Intensive Care Unit Patient
* Issues in Cost Effectiveness
* Withdrawal of Life Support
* Future [Editorial Discussion |
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| About The Author: |
Edwin A Deitch
Professor and Chairman, Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark USA
Professor Jean-Louis Vincent, Head, Dept of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussel, Belgium
Mr Alistair Windsor, Tutor in Surgery, St Mark's Hospital, Northwick Park, Harrow, United Kingdom |
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