Lung Cancer Volume 2: Diagnostic and Therapeutic Methods and Reviews
Leading physician scientists and noted researchers describe step-by-step techniques for lung cancer diagnosis based on the molecular analysis of clinical samples. These experts review currently accepted treatments and outline a variety of novel therapies, including those based on gene therapy, immunotherapy, and chemoprevention, and show how these newly improved techniques can give a better appreciation of the prognosis associated with the particular mutation uncovered by the technique. These methods use a variety of molecular techniques, including the manipulation of gene expression and the alteration of immune status, to combat lung cancer.
| Author: |
Barbara Driscoli |
| ISBN: |
089603920X |
| Publisher: |
Humana Press |
| Binding: |
Hardcover |
| Year Published: |
end Dec 2002 |
| No. of Pages: |
840 |
| Illustrations: |
Driscoli |
| Contents: |
Part I. Introduction
* Molecular and Genetic Aspects of Lung Cancer
Part II. Detection of Altered Tumor Markers in Clinical Samples for Diagnosis and Prognosis
A. Molecular Methods for Prognostic Detection of Altered Tumor Markers: Clinical Implications
* Molecular Alterations in Lung Cancer: Impact on Prognosis
* Cellular Predictive Factors of Drug Resistance in Non-Small Cell Lung Carcinomas
* Clinical Implications of p53 Mutations in Lung Cancer
* An Epidemiologic and Clinicopathologic Overview of AIDS-Associated Pulmonary Kaposi's Sarcoma
* Myeloperoxidase Promoter Region Polymorphism and Lung Cancer Risk
* Clinical Utility of Tumor Markers in the Management of Non-Small Cell Lung Cancer
B. Molecular Methods for Prognostic Detection of Altered Lung Tumor Markers in Clinical Samples
* I. DNA-Based Analysis. Detection of Chromosomal Aberrations in Lung Tissue and Peripheral Blood Lymphocytes Using Interphase Fluorescence In Situ Hybridizati
* In Situ Analysis of Telomerase RNA Gene Expression as a Marker for Tumor Progression
* A High-Throughput Methodology for Identifying Molecular Targets Overexpressed in Lung Cancers
* Expression Profiling of Lung Cancer Based on Suppression Subtraction Hybridization (SSH)
* Comparative Genomic Hybridization of Human Lung Cancer
* Sensitive Assays for Detection of Lung Cancer: Molecular Markers in Blood Samples
* Fluorescent Microsatellite Analysis in Bronchial Lavage as a Potential Diagnostic Tool for Lung Cancer
* Southern Blotting of Genomic DNA from Lung and Its Tumors: Application to Analysis of Allele Loss on Chromosome 11p15.5
* Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
II. PCR-Based Analyses. Comparative Multiplex PCR and Allele-Specific Expression Analysis in Human Lung Cancer: Tools to Facilitate Target Identification
* Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT
* Detection of K-ras and p53 Mutations by “Mutant-Enriched” PCR-RFLP
* Detection of Small Cell Lung Cancer by RT-PCR for Neuropeptides, Neuropeptide Receptors, or a Splice Variant of the Neuron Restrictive Silencer Factor
III. Immunohistochemical Analyses
* Utilization of Thyroid Transcription Factor-1 Immunostaining in the Diagnosis of Lung Tumors
* Molecular Biologic Substaining of Stage I NSCLC Through Immunohistochemistry Performed on Formalin-Fixed, Paraffin-Embedded Tissue
* A Sensitive Immunofluorescence Assay for Detection of p53 Protein in the Sputum
* SPR1: An Early Molecular Marker for Bronchial Carcinogenesis
* Determination of Biological Parameters on Fine-Needle Aspirates from Non-Small Cell Lung Cancer
IV. Imaging Analysis
* Detection and Analysis of Lung Cancer Cells from Body Fluids Using a Rare Event Imaging System
* Reconstruction of Geno-Phenotypic Evolutionary Sequences from Intracellular Patterns of Molecular Abnormalities in Human Solid Tumors
Part III. Novel Therapies
A. Introduction to Current Treatments
* Surgical Treatment of Lung Cancer: Past and Present
* Recent Advances and Dilemmas in the Radiotherapeutic Management of * Locally Advanced Non-Small Cell Lung Cancer
Photodynamic Therapy in Lung Cancer: A Review
B. Gene Therapies
I. Overview: Advantages and Pitfalls of Lung-Targeted Gene Therapies
* Gene Therapy for Lung Cancer: An Introduction
* Identifying Obstacles to Viral Gene Therapy for Lung Cancer: Malignant Pleural Effusions as a Paradigm
* Topical Gene Therapy for Pulmonary Diseases with PEI-DNA Aerosol Complexes
II. Plasmid and Virus-Based Gene Therapies
* Targeted Delivery of Expression Plasmids to the Lung via Macroaggregated Polyethylenimine-Albumin Conjugates
* Preparation of Retroviral Vectors for Cell-Cycle-Targeted Gene Therapy of Lung Cancer
* Aerosol Gene Therapy for Metastatic Lung Cancer Using PEI-p53 Complexes
III. Antisense Oligonucleotide Gene Therapies
* Clinical Development of Antisense Oligonucleotides as Anti-Cancer Therapeutics
* Antisense Oligonucleotides Targeting RIa Subunit of Protein Kinase A: In Vitro and In Vivo Anti-Tumor Activity and Pharmacokinetics
* Use of Antisense Oligonucleotides for Therapy: Manipulation of Apoptosis Inhibitors for Destruction of Lung Cancer Cells
* Induction of Programmed Cell Death with an Antisense Bcl-2 Oligonucleotide
C. Immune Therapies
* Tumor Vaccination with Cytokine-Encapsulated Microspheres
* Adoptive Immunotherapy
* Intratumoral Therapy with Cytokine Gene-Modified Dendritic Cells in Murine Lung Cancer Models
* Cyclooxygenase 2-Dependent Regulation of Antitumor Immunity in Lung Cancer
D. Chemoprevention
* Chemoprevention of Lung Cancer
* Assessing the Interaction of Particulate Delivery Systems with Lung Surfactant
* Chemopreventive Therapeutics: Inhalation Therapies for Lung Cancer and Bronchial Premalignancy
INDEX
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